› 4ot2

X-ray diffraction
2.42Å resolution

Crystal Structure of Equine Serum Albumin in complex with Naproxen

Released:
DOI: 10.2210/pdb4ot2/pdb
PDB entry 4ot2 coloured by chain, front view.
PDB entry 4ot2 coloured by chain, side view.
PDB entry 4ot2 coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Structural studies of bovine, equine, and leporine serum albumin complexes with naproxen.
Bujacz A, Zielinski K, Sekula B
Proteins 82 2199-208 (2014)
PMID: 24753230

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153012 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 583 amino acids
Theoretical weight: 65.85 KDa
Source organism: Equus caballus
UniProt:
  • Canonical: P35747 (Residues: 25-607; Coverage: 99%)
Gene name: ALB
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

4 bound ligands:
Ligand NPS 2 x NPS
Ligand SIN 1 x SIN
Ligand ACT 2 x ACT
Ligand MLI 4 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P61
Unit cell:
a: 93.77Å b: 93.77Å c: 142.41Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.182 0.179 0.247

Quick links

Citations

1 review citation

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering.
Meng et al. (2023)
32 other articles

6 mentions without citation

Testosterone meets albumin - the molecular mechanism of sex hormone transport by serum albumins.
Czub et al. (2019)
5 more