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Structure of Cathepsin D with inhibitor 2-(3,4-dimethoxyphenyl)-N-[N-(4-methylbenzyl)carbamimidoyl]acetamide

Source organism: Homo sapiens
Biochemical function: aspartic-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.23.5: Cathepsin D

Reaction catalysed:
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
Systematic name:
-

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00026
Domain description: Eukaryotic aspartyl protease
Occurring in:
  1. Cathepsin D heavy chain
The deposited structure of PDB entry 4obz contains 2 copies of Pfam domain PF00026 (Eukaryotic aspartyl protease) in Cathepsin D heavy chain. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001461
Domain description: Aspartic peptidase A1 family
Occurring in:
  1. Cathepsin D light chain
  2. Cathepsin D heavy chain
IPR033121
Domain description: Peptidase family A1 domain
Occurring in:
  1. Cathepsin D light chain
  2. Cathepsin D heavy chain
IPR021109
Domain description: Aspartic peptidase domain superfamily
Occurring in:
  1. Cathepsin D light chain
  2. Cathepsin D heavy chain
IPR001969
Domain description: Aspartic peptidase, active site
Occurring in:
  1. Cathepsin D light chain
  2. Cathepsin D heavy chain

Structure domain

CATH CATH domain
2.40.70.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Cathepsin D, subunit A; domain 1
Homology: Acid Proteases
Occurring in:
  1. Cathepsin D light chain
  2. Cathepsin D heavy chain
The deposited structure of PDB entry 4obz contains 2 copies of CATH domain 2.40.70.10 (Cathepsin D, subunit A; domain 1) in Cathepsin D light chain. Showing 1 copy in chain C.
The deposited structure of PDB entry 4obz contains 2 copies of CATH domain 2.40.70.10 (Cathepsin D, subunit A; domain 1) in Cathepsin D heavy chain. Showing 1 copy in chain B.

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