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Crystal Structure of Human Farnesyl Pyrophosphate Synthase (Y204F) Mutant Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate

X-ray diffraction
1.96Å resolution
PDB entry 4kpd coloured by chain, front view.
PDB entry 4kpd coloured by chain, side view.
PDB entry 4kpd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Farnesyl pyrophosphate synthase
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Multimeric state: homo dimer
Accessible surface area: 26208.05 Å2
Buried surface area: 6971.43 Å2
Dissociation area: 1,987.9 Å2
Dissociation energy (ΔGdiss): 22.24 kcal/mol
Dissociation entropy (TΔSdiss): 14.13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-146902

Macromolecules

Farnesyl pyrophosphate synthase
Chain: A
Length: 375 amino acids
Theoretical weight: 43.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14324 (Residues: 67-419; Coverage: 84%)
Gene names: FDPS, FPS, KIAA1293
Pfam: Polyprenyl synthetase
InterPro:
CATH: Farnesyl Diphosphate Synthase
Farnesyl pyrophosphate synthase in PDB entry 4kpd, assembly 1, front view.
Farnesyl pyrophosphate synthase in PDB entry 4kpd, assembly 1, side view.
Farnesyl pyrophosphate synthase in PDB entry 4kpd, assembly 1, top view.
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