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Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin

Source organisms:
Biochemical function: host cell surface receptor binding
Biological process: fusion of virus membrane with host plasma membrane
Cellular component: viral envelope

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00509
Domain description: Haemagglutinin
Occurring in:
  1. Hemagglutinin HA1 chain
  2. Hemagglutinin HA2 chain
The deposited structure of PDB entry 4hg4 contains 9 copies of Pfam domain PF00509 (Haemagglutinin) in Hemagglutinin HA1 chain. Showing 1 copy in chain O [auth H].
The deposited structure of PDB entry 4hg4 contains 9 copies of Pfam domain PF00509 (Haemagglutinin) in Hemagglutinin HA2 chain. Showing 1 copy in chain F [auth c].

InterPro InterPro annotations
IPR000149
Domain description: Haemagglutinin, influenzavirus A
Occurring in:
  1. Hemagglutinin HA1 chain
IPR001364
Domain description: Haemagglutinin, influenzavirus A/B
Occurring in:
  1. Hemagglutinin HA1 chain
  2. Hemagglutinin HA2 chain
IPR000386
Domain description: Haemagglutinin, influenzavirus B
Occurring in:
  1. Hemagglutinin HA2 chain
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Fab 2G1 heavy chain
  2. Fab 2G1 light chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Fab 2G1 heavy chain
  2. Fab 2G1 light chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Fab 2G1 heavy chain
  2. Fab 2G1 light chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Fab 2G1 heavy chain
  2. Fab 2G1 light chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Fab 2G1 heavy chain
  2. Fab 2G1 light chain
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Fab 2G1 heavy chain
  2. Fab 2G1 light chain
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Fab 2G1 heavy chain
  2. Fab 2G1 light chain
IPR013828
Domain description: Haemagglutinin, HA1 chain, alpha/beta domain superfamily
Occurring in:
  1. Hemagglutinin HA1 chain
IPR008980
Domain description: Viral capsid/haemagglutinin protein
Occurring in:
  1. Hemagglutinin HA1 chain

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Fab 2G1 heavy chain
  2. Fab 2G1 light chain
The deposited structure of PDB entry 4hg4 contains 16 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Fab 2G1 heavy chain. Showing 2 copies in chain W [auth N].
The deposited structure of PDB entry 4hg4 contains 14 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Fab 2G1 light chain. Showing 2 copies in chain V [auth M].
2.10.77.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Hemagglutinin; Chain A, domain 2
Homology: Hemagglutinin Chain A, Domain 2
Occurring in:
  1. Hemagglutinin HA1 chain
The deposited structure of PDB entry 4hg4 contains 9 copies of CATH domain 2.10.77.10 (Hemagglutinin; Chain A, domain 2) in Hemagglutinin HA1 chain. Showing 1 copy in chain O [auth H].
3.90.20.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Hemagglutinin Ectodomain; Chain B
Homology: Hemagglutinin Ectodomain; Chain B
Occurring in:
  1. Hemagglutinin HA2 chain
The deposited structure of PDB entry 4hg4 contains 9 copies of CATH domain 3.90.20.10 (Hemagglutinin Ectodomain; Chain B) in Hemagglutinin HA2 chain. Showing 1 copy in chain F [auth c].
3.90.209.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Homology: Hemagglutinin (Ha1 Chain); Chain: A; domain 1
Occurring in:
  1. Hemagglutinin HA1 chain
The deposited structure of PDB entry 4hg4 contains 9 copies of CATH domain 3.90.209.20 (Hemagglutinin (Ha1 Chain); Chain: A; domain 1) in Hemagglutinin HA1 chain. Showing 1 copy in chain O [auth H].

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