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Kynurenine Aminotransferase II Inhibitors

X-ray diffraction
2.15Å resolution
PDB entry 4geb coloured by chain, front view.
PDB entry 4geb coloured by chain, side view.
PDB entry 4geb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
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Multimeric state: homo dimer
Accessible surface area: 31042.06 Å2
Buried surface area: 10011.04 Å2
Dissociation area: 4,676.9 Å2
Dissociation energy (ΔGdiss): 93.44 kcal/mol
Dissociation entropy (TΔSdiss): 15.39 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-185410

Macromolecules

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Chains: A, B
Length: 439 amino acids
Theoretical weight: 48.95 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8N5Z0 (Residues: 1-425; Coverage: 100%)
Gene names: AADAT, KAT2, KYAT2
Pfam: Aminotransferase class I and II
InterPro:
CATH:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial in PDB entry 4geb, assembly 1, front view.
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial in PDB entry 4geb, assembly 1, side view.
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial in PDB entry 4geb, assembly 1, top view.
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