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Co-crystal structure of Rap1 in complex with KRIT1

Source organism: Homo sapiens
Biochemical function: protein-containing complex binding
Biological process: negative regulation of synaptic vesicle exocytosis
Cellular component: cytoskeleton

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EC 3.6.5.2: Small monomeric GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00373
Domain description: FERM central domain
Occurring in:
  1. Krev interaction trapped protein 1
The deposited structure of PDB entry 4dxa contains 1 copy of Pfam domain PF00373 (FERM central domain) in Krev interaction trapped protein 1. Showing 1 copy in chain B.

PF00071
Domain description: Ras family
Occurring in:
  1. Ras-related protein Rap-1b
The deposited structure of PDB entry 4dxa contains 1 copy of Pfam domain PF00071 (Ras family) in Ras-related protein Rap-1b. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001806
Domain description: Small GTPase
Occurring in:
  1. Ras-related protein Rap-1b
IPR019748
Domain description: FERM central domain
Occurring in:
  1. Krev interaction trapped protein 1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Ras-related protein Rap-1b
IPR041791
Domain description: Krev interaction trapped protein 1, FERM domain C-lobe
Occurring in:
  1. Krev interaction trapped protein 1
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Krev interaction trapped protein 1
IPR035963
Domain description: FERM superfamily, second domain
Occurring in:
  1. Krev interaction trapped protein 1
IPR014352
Domain description: FERM/acyl-CoA-binding protein superfamily
Occurring in:
  1. Krev interaction trapped protein 1
IPR000299
Domain description: FERM domain
Occurring in:
  1. Krev interaction trapped protein 1
IPR019749
Domain description: Band 4.1 domain
Occurring in:
  1. Krev interaction trapped protein 1
IPR038851
Domain description: Ras-related protein Rap1
Occurring in:
  1. Ras-related protein Rap-1b
IPR020849
Domain description: Small GTPase, Ras-type
Occurring in:
  1. Ras-related protein Rap-1b
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. Ras-related protein Rap-1b

Structure domains

CATH CATH domains
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Krev interaction trapped protein 1
The deposited structure of PDB entry 4dxa contains 1 copy of CATH domain 2.30.29.30 (PH-domain like) in Krev interaction trapped protein 1. Showing 1 copy in chain B.
1.20.80.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Acyl-CoA Binding Protein
Homology: Acyl-CoA Binding Protein
Occurring in:
  1. Krev interaction trapped protein 1
The deposited structure of PDB entry 4dxa contains 1 copy of CATH domain 1.20.80.10 (Acyl-CoA Binding Protein) in Krev interaction trapped protein 1. Showing 1 copy in chain B.
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Krev interaction trapped protein 1
The deposited structure of PDB entry 4dxa contains 1 copy of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Krev interaction trapped protein 1. Showing 1 copy in chain B.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Ras-related protein Rap-1b
The deposited structure of PDB entry 4dxa contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Ras-related protein Rap-1b. Showing 1 copy in chain A.

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