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CID of human RPRD1B in complex with an unmodified CTD peptide

X-ray diffraction
1.85Å resolution
PDB entry 4q96 coloured by chain, front view.
PDB entry 4q96 coloured by chain, side view.
PDB entry 4q96 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo dimer
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Regulation of nuclear pre-mRNA domain-containing protein 1B
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Multimeric state: homo dimer
Accessible surface area: 13457.33 Å2
Buried surface area: 3621.8 Å2
Dissociation area: 1,586.97 Å2
Dissociation energy (ΔGdiss): 23.84 kcal/mol
Dissociation entropy (TΔSdiss): 12.35 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-192503
Assembly 2
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Assembly Name: Regulation of nuclear pre-mRNA domain-containing protein 1B
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Multimeric state: homo dimer
Accessible surface area: 13601.86 Å2
Buried surface area: 3432.1 Å2
Dissociation area: 1,645.26 Å2
Dissociation energy (ΔGdiss): 24.1 kcal/mol
Dissociation entropy (TΔSdiss): 12.38 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-192503
Assembly 3 (preferred)
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Assembly Name: Regulation of nuclear pre-mRNA domain-containing protein 1B
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Multimeric state: hetero hexamer
Accessible surface area: 24953.93 Å2
Buried surface area: 14808.86 Å2
Dissociation area: 3,460.9 Å2
Dissociation energy (ΔGdiss): 28.43 kcal/mol
Dissociation entropy (TΔSdiss): 19.44 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-165083

Macromolecules

Regulation of nuclear pre-mRNA domain-containing protein 1B
Chains: A, B, D, E
Length: 135 amino acids
Theoretical weight: 15.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQG5 (Residues: 2-135; Coverage: 41%)
Gene names: C20orf77, CREPT, RPRD1B
Pfam: CID domain
InterPro:
CATH: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Regulation of nuclear pre-mRNA domain-containing protein 1B in PDB entry 4q96, assembly 3, front view.
Regulation of nuclear pre-mRNA domain-containing protein 1B in PDB entry 4q96, assembly 3, side view.
Regulation of nuclear pre-mRNA domain-containing protein 1B in PDB entry 4q96, assembly 3, top view.
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RPB1-CTD
Chains: C, F
Length: 21 amino acids
Theoretical weight: 2.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
InterPro: RNA polymerase II, heptapeptide repeat, eukaryotic
RPB1-CTD in PDB entry 4q96, assembly 3, front view.
RPB1-CTD in PDB entry 4q96, assembly 3, side view.
RPB1-CTD in PDB entry 4q96, assembly 3, top view.
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