RNA polymerase II, heptapeptide repeat, eukaryotic (IPR000684)

Short name: RNA_pol_II_repeat_euk


RNA polymerase II (EC: [PMID: 1883205, PMID: 1700503] is one of the three forms of RNA polymerase that exist in eukaryotic nuclei. The C-terminal region of the largest subunit of this oligomeric enzyme consists of the tandem repeat of a conserved heptapeptide [PMID: 2251729]. The number of repeats varies according to the species (for example there are 17 in Plasmodium, 26 in yeast, 44 in Drosophila, and 52 in mammals). The region containing these repeats is essential for the function of polymerase II. This repeated heptapeptide (called CT7n or CTD) is rich in hydroxyl groups. It probably projects out of the globular catalytic domain and may interact with the acidic activator domains of transcriptional regulatory proteins. It is also known to bind by intercalation to DNA. RNA polymerase II is activated by phosphorylation. The serine and threonine residues in the CT7n repeats are the target of such phosphorylation.

GO terms

Biological Process

GO:0006366 transcription by RNA polymerase II

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0005665 DNA-directed RNA polymerase II, core complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns