› › Structure analysis

AKAP13 (AKAP-Lbc) RhoGEF domain in complex with RhoA

X-ray diffraction
2.1Å resolution
PDB entry 4d0n coloured by chain, front view.
PDB entry 4d0n coloured by chain, side view.
PDB entry 4d0n coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: A-kinase anchor protein 13 and Transforming protein RhoA
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 25983.85 Å2
Buried surface area: 4730.81 Å2
Dissociation area: 1,567.33 Å2
Dissociation energy (ΔGdiss): 19.6 kcal/mol
Dissociation entropy (TΔSdiss): 13.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158278

Macromolecules

Transforming protein RhoA
Chain: A
Length: 185 amino acids
Theoretical weight: 20.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61586 (Residues: 1-184; Coverage: 95%)
Gene names: ARH12, ARHA, RHO12, RHOA
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Transforming protein RhoA in PDB entry 4d0n, assembly 1, front view.
Transforming protein RhoA in PDB entry 4d0n, assembly 1, side view.
Transforming protein RhoA in PDB entry 4d0n, assembly 1, top view.
Molecule details ›

Search similar proteins

A-kinase anchor protein 13
Chain: B
Length: 373 amino acids
Theoretical weight: 43.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12802 (Residues: 1968-2338; Coverage: 13%)
Gene names: AKAP13, BRX, HT31, LBC
Pfam:
InterPro:
CATH:
A-kinase anchor protein 13 in PDB entry 4d0n, assembly 1, front view.
A-kinase anchor protein 13 in PDB entry 4d0n, assembly 1, side view.
A-kinase anchor protein 13 in PDB entry 4d0n, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links