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Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state

X-ray diffraction
2.6Å resolution
PDB entry 3vn9 coloured by chain, front view.
PDB entry 3vn9 coloured by chain, side view.
PDB entry 3vn9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dual specificity mitogen-activated protein kinase kinase 6
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Multimeric state: monomeric
Accessible surface area: 13809.66 Å2
Buried surface area: 97.84 Å2
Dissociation area: 48.92 Å2
Dissociation energy (ΔGdiss): 11.22 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156562

Macromolecules

Dual specificity mitogen-activated protein kinase kinase 6
Chain: A
Length: 340 amino acids
Theoretical weight: 38.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52564 (Residues: 1-334; Coverage: 100%)
Gene names: MAP2K6, MEK6, MKK6, PRKMK6, SKK3
Pfam: Protein kinase domain
InterPro:
CATH:
Dual specificity mitogen-activated protein kinase kinase 6 in PDB entry 3vn9, assembly 1, front view.
Dual specificity mitogen-activated protein kinase kinase 6 in PDB entry 3vn9, assembly 1, side view.
Dual specificity mitogen-activated protein kinase kinase 6 in PDB entry 3vn9, assembly 1, top view.
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