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Crystal Structure of USP2 in complex with mutated ubiquitin

Source organism: Homo sapiens
Biochemical function: cysteine-type deubiquitinase activity
Biological process: protein deubiquitination
Cellular component: not assigned

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EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 3v6c contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain B.

PF00443
Domain description: Ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 2
The deposited structure of PDB entry 3v6c contains 1 copy of Pfam domain PF00443 (Ubiquitin carboxyl-terminal hydrolase) in Ubiquitin carboxyl-terminal hydrolase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin
IPR018200
Domain description: Ubiquitin specific protease, conserved site
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 2
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin
IPR001394
Domain description: Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 2
IPR028889
Domain description: Ubiquitin specific protease domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 2
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 2
IPR038418
Domain description: 6-pyruvoyl tetrahydropterin synthase/QueD superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 2

Structure domains

CATH CATH domains
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 3v6c contains 1 copy of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Ubiquitin. Showing 1 copy in chain B.
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase 2
The deposited structure of PDB entry 3v6c contains 1 copy of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Ubiquitin carboxyl-terminal hydrolase 2. Showing 1 copy in chain A.

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