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Crystal Structure of the Human Nur77 Ligand-binding Domain

X-ray diffraction
2.06Å resolution
PDB entry 3v3e coloured by chain, front view.
PDB entry 3v3e coloured by chain, side view.
PDB entry 3v3e coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nuclear receptor subfamily 4immunitygroup A member 1
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Multimeric state: homo dimer
Accessible surface area: 22153.0 Å2
Buried surface area: 2026.19 Å2
Dissociation area: 592 Å2
Dissociation energy (ΔGdiss): 2.23 kcal/mol
Dissociation entropy (TΔSdiss): 12.78 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149785

Macromolecules

Nuclear receptor subfamily 4immunitygroup A member 1
Chains: A, B
Length: 257 amino acids
Theoretical weight: 28.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22736 (Residues: 351-598; Coverage: 42%)
Gene names: GFRP1, HMR, NAK1, NR4A1
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
Nuclear receptor subfamily 4immunitygroup A member 1 in PDB entry 3v3e, assembly 1, front view.
Nuclear receptor subfamily 4immunitygroup A member 1 in PDB entry 3v3e, assembly 1, side view.
Nuclear receptor subfamily 4immunitygroup A member 1 in PDB entry 3v3e, assembly 1, top view.
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