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Crystal Structure of the L-2-Haloacid Dehalogenase RSc1362

Source organism: Ralstonia solanacearum
Biochemical function: metal ion binding
Biological process: not assigned
Cellular component: not assigned

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EC 3.8.1.2: (S)-2-haloacid dehalogenase

Reaction catalysed:
(S)-2-haloacid + H(2)O = (R)-2-hydroxyacid + halide
Systematic name:
(S)-2-haloacid halidohydrolase
Alternative Name(s):
  • 2-haloacid dehalogenase
  • 2-haloacid halidohydrolase
  • 2-haloalkanoic acid dehalogenase
  • 2-haloalkanoid acid halidohydrolase
  • 2-halocarboxylic acid dehalogenase II
  • DL-2-haloacid dehalogenase
  • Halocarboxylic acid halidohydrolase
  • L-2-haloacid dehalogenase
  • L-DEX

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00702
Domain description: haloacid dehalogenase-like hydrolase
Occurring in:
  1. (S)-2-haloacid dehalogenase
The deposited structure of PDB entry 3umb contains 1 copy of Pfam domain PF00702 (haloacid dehalogenase-like hydrolase) in (S)-2-haloacid dehalogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006439
Domain description: HAD hydrolase, subfamily IA
Occurring in:
  1. (S)-2-haloacid dehalogenase
IPR006328
Domain description: L-2-Haloacid dehalogenase
Occurring in:
  1. (S)-2-haloacid dehalogenase
IPR023198
Domain description: Phosphoglycolate phosphatase-like, domain 2
Occurring in:
  1. (S)-2-haloacid dehalogenase
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. (S)-2-haloacid dehalogenase
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. (S)-2-haloacid dehalogenase

Structure domains

CATH CATH domains
3.40.50.1000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HAD superfamily/HAD-like
Occurring in:
  1. (S)-2-haloacid dehalogenase
The deposited structure of PDB entry 3umb contains 1 copy of CATH domain 3.40.50.1000 (Rossmann fold) in (S)-2-haloacid dehalogenase. Showing 1 copy in chain A.
1.10.150.240
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: Putative phosphatase; domain 2
Occurring in:
  1. (S)-2-haloacid dehalogenase
The deposited structure of PDB entry 3umb contains 1 copy of CATH domain 1.10.150.240 (DNA polymerase; domain 1) in (S)-2-haloacid dehalogenase. Showing 1 copy in chain A.

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