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Ribonucleotide Reductase Dimanganese(II)-NrdF from Escherichia coli

Source organism: Escherichia coli K-12
Biochemical function: metal ion binding
Biological process: 2'-deoxyribonucleotide biosynthetic process
Cellular component: ribonucleoside-diphosphate reductase complex

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EC 1.17.4.1: Ribonucleoside-diphosphate reductase

Reaction catalysed:
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin
Systematic name:
2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
Alternative Name(s):
  • 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase
  • ADP reductase
  • CDP reductase
  • NrdB (gene name)
  • NrdF (gene name)
  • NrdJ (gene name)
  • Nucleoside diphosphate reductase
  • RR
  • Ribonucleoside 5'-diphosphate reductase
  • Ribonucleoside diphosphate reductase
  • Ribonucleotide diphosphate reductase
  • Ribonucleotide reductase
  • UDP reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00268
Domain description: Ribonucleotide reductase, small chain
Occurring in:
  1. Ribonucleoside-diphosphate reductase 2 subunit beta
The deposited structure of PDB entry 3n37 contains 1 copy of Pfam domain PF00268 (Ribonucleotide reductase, small chain) in Ribonucleoside-diphosphate reductase 2 subunit beta. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000358
Domain description: Ribonucleotide reductase small subunit family
Occurring in:
  1. Ribonucleoside-diphosphate reductase 2 subunit beta
IPR030475
Domain description: Ribonucleotide reductase small subunit, acitve site
Occurring in:
  1. Ribonucleoside-diphosphate reductase 2 subunit beta
IPR033909
Domain description: Ribonucleotide reductase small subunit
Occurring in:
  1. Ribonucleoside-diphosphate reductase 2 subunit beta
IPR026494
Domain description: Ribonucleoside-diphosphate reductase subunit beta
Occurring in:
  1. Ribonucleoside-diphosphate reductase 2 subunit beta
IPR009078
Domain description: Ferritin-like superfamily
Occurring in:
  1. Ribonucleoside-diphosphate reductase 2 subunit beta
IPR012348
Domain description: Ribonucleotide reductase-like
Occurring in:
  1. Ribonucleoside-diphosphate reductase 2 subunit beta

Structure domain

CATH CATH domain
1.10.620.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Ribonucleotide Reductase, subunit A
Homology: Ribonucleotide Reductase, subunit A
Occurring in:
  1. Ribonucleoside-diphosphate reductase 2 subunit beta
The deposited structure of PDB entry 3n37 contains 1 copy of CATH domain 1.10.620.20 (Ribonucleotide Reductase, subunit A) in Ribonucleoside-diphosphate reductase 2 subunit beta. Showing 1 copy in chain A.

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