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Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase

X-ray diffraction
3Å resolution
PDB entry 3i6u coloured by chain, front view.
PDB entry 3i6u coloured by chain, side view.
PDB entry 3i6u coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase Chk2
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Multimeric state: homo dimer
Accessible surface area: 37024.9 Å2
Buried surface area: 4681.43 Å2
Dissociation area: 2,340.71 Å2
Dissociation energy (ΔGdiss): 13.83 kcal/mol
Dissociation entropy (TΔSdiss): 15.13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-132134

Macromolecules

Serine/threonine-protein kinase Chk2
Chains: A, B
Length: 419 amino acids
Theoretical weight: 48.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96017 (Residues: 84-502; Coverage: 77%)
Gene names: CDS1, CHEK2, CHK2, RAD53
Pfam:
InterPro:
CATH:
Serine/threonine-protein kinase Chk2 in PDB entry 3i6u, assembly 1, front view.
Serine/threonine-protein kinase Chk2 in PDB entry 3i6u, assembly 1, side view.
Serine/threonine-protein kinase Chk2 in PDB entry 3i6u, assembly 1, top view.
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