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Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP

Source organisms:
Biochemical function: protein binding
Biological process: snRNA import into nucleus
Cellular component: cytosol

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00071
Domain description: Ras family
Occurring in:
  1. GTP-binding nuclear protein Ran
The deposited structure of PDB entry 3gjx contains 2 copies of Pfam domain PF00071 (Ras family) in GTP-binding nuclear protein Ran. Showing 1 copy in chain B [auth C].

PF11538
Domain description: Snurportin1
Occurring in:
  1. Snurportin-1
The deposited structure of PDB entry 3gjx contains 2 copies of Pfam domain PF11538 (Snurportin1) in Snurportin-1. Showing 1 copy in chain D [auth E].

PF08767
Domain description: CRM1 C terminal
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 3gjx contains 2 copies of Pfam domain PF08767 (CRM1 C terminal) in Exportin-1. Showing 1 copy in chain C [auth A].

PF18787
Domain description: CRM1 / Exportin repeat 3
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 3gjx contains 2 copies of Pfam domain PF18787 (CRM1 / Exportin repeat 3) in Exportin-1. Showing 1 copy in chain C [auth A].

PF18784
Domain description: CRM1 / Exportin repeat 2
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 3gjx contains 2 copies of Pfam domain PF18784 (CRM1 / Exportin repeat 2) in Exportin-1. Showing 1 copy in chain C [auth A].

PF18777
Domain description: Chromosome region maintenance or exportin repeat
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 3gjx contains 2 copies of Pfam domain PF18777 (Chromosome region maintenance or exportin repeat) in Exportin-1. Showing 1 copy in chain C [auth A].

PF08389
Domain description: Exportin 1-like protein
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 3gjx contains 2 copies of Pfam domain PF08389 (Exportin 1-like protein) in Exportin-1. Showing 1 copy in chain C [auth A].

PF03810
Domain description: Importin-beta N-terminal domain
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 3gjx contains 2 copies of Pfam domain PF03810 (Importin-beta N-terminal domain) in Exportin-1. Showing 1 copy in chain C [auth A].

InterPro InterPro annotations
IPR002041
Domain description: Ran GTPase
Occurring in:
  1. GTP-binding nuclear protein Ran
IPR001806
Domain description: Small GTPase
Occurring in:
  1. GTP-binding nuclear protein Ran
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. GTP-binding nuclear protein Ran
IPR017336
Domain description: Snurportin-1
Occurring in:
  1. Snurportin-1
IPR001494
Domain description: Importin-beta, N-terminal domain
Occurring in:
  1. Exportin-1
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Exportin-1
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. GTP-binding nuclear protein Ran
IPR047857
Domain description: Snurportin-1, m3G cap-binding domain
Occurring in:
  1. Snurportin-1
IPR024721
Domain description: Snurportin-1, N-terminal
Occurring in:
  1. Snurportin-1
IPR002652
Domain description: Importin-alpha, importin-beta-binding domain
Occurring in:
  1. Snurportin-1
IPR014877
Domain description: Exportin-1, C-terminal
Occurring in:
  1. Exportin-1
IPR040485
Domain description: Exportin-1, repeat 3
Occurring in:
  1. Exportin-1
IPR041235
Domain description: Exportin-1, repeat 2
Occurring in:
  1. Exportin-1
IPR041123
Domain description: Chromosome region maintenance repeat
Occurring in:
  1. Exportin-1
IPR013598
Domain description: Exportin-1/Importin-beta-like
Occurring in:
  1. Exportin-1
IPR045065
Domain description: Exportin-1/5
Occurring in:
  1. Exportin-1
IPR011989
Domain description: Armadillo-like helical
Occurring in:
  1. Exportin-1

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. GTP-binding nuclear protein Ran
The deposited structure of PDB entry 3gjx contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in GTP-binding nuclear protein Ran. Showing 1 copy in chain B [auth C].
3.30.470.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-amino Acid Aminotransferase; Chain A, domain 1
Homology: DNA ligase/mRNA capping enzyme
Occurring in:
  1. Snurportin-1
The deposited structure of PDB entry 3gjx contains 2 copies of CATH domain 3.30.470.30 (D-amino Acid Aminotransferase; Chain A, domain 1) in Snurportin-1. Showing 1 copy in chain D [auth E].
1.25.10.10
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Leucine-rich Repeat Variant
Homology: Leucine-rich Repeat Variant
Occurring in:
  1. Exportin-1
The deposited structure of PDB entry 3gjx contains 1 copy of CATH domain 1.25.10.10 (Leucine-rich Repeat Variant) in Exportin-1. Showing 1 copy in chain F [auth D].

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