Exportin-1/Importin-beta-like (IPR013598)

Short name: Exportin-1/Importin-b-like

Overlapping homologous superfamilies

Domain relationships



The exchange of macromolecules between the nucleus and cytoplasm takes place through nuclear pore complexes within the nuclear membrane. Active transport of large molecules through these pore complexes require carrier proteins, called karyopherins (importins and exportins), which shuttle between the two compartments.

This domain is found close to the N terminus of yeast exportin 1 (Xpo1, Crm1, P14068), as well as adjacent to the N-terminal domain of importin-beta (IPR001494). Exportin 1 is a nuclear export receptor that translocates proteins out of the nucleus; it interacts with leucine-rich nuclear export signal (NES) sequences in proteins to be transported, as well as with RanGTP [PMID: 9323132, PMID: 9323123]. Importin-beta is a nuclear import receptor that translocates proteins into the nucleus; it interacts with RanGTP and importin-alpha, the latter binding with the nuclear localisation signal (NLS) sequences in proteins to be transported [PMID: 17170104].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.