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Fragment based discovery of JAK-2 inhibitors

X-ray diffraction
1.922Å resolution
PDB entry 3e62 coloured by chain, front view.
PDB entry 3e62 coloured by chain, side view.
PDB entry 3e62 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase JAK2
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-130063

Macromolecules

Tyrosine-protein kinase JAK2
Chain: A
Length: 293 amino acids
Theoretical weight: 34.68 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: O60674 (Residues: 839-1131; Coverage: 26%)
Gene name: JAK2
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase JAK2 in PDB entry 3e62, assembly 1, front view.
Tyrosine-protein kinase JAK2 in PDB entry 3e62, assembly 1, side view.
Tyrosine-protein kinase JAK2 in PDB entry 3e62, assembly 1, top view.
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