› › Structure analysis

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

X-ray diffraction
1.8Å resolution
PDB entry 3dac coloured by chain, front view.
PDB entry 3dac coloured by chain, side view.
PDB entry 3dac coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Cellular tumor antigen p53 and Protein Mdm4
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 5529.56 Å2
Buried surface area: 1024.02 Å2
Dissociation area: 512.01 Å2
Dissociation energy (ΔGdiss): 5.15 kcal/mol
Dissociation entropy (TΔSdiss): 7.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138120
Assembly 2
Download    3D Visualisation
Assembly Name: Cellular tumor antigen p53 and Protein Mdm4
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 5734.49 Å2
Buried surface area: 1118.86 Å2
Dissociation area: 559.43 Å2
Dissociation energy (ΔGdiss): 5.19 kcal/mol
Dissociation entropy (TΔSdiss): 7.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138120

Macromolecules

Protein Mdm4
Chains: A, M
Length: 130 amino acids
Theoretical weight: 14.77 KDa
Source organism: Danio rerio
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7ZUW7 (Residues: 15-129; Coverage: 23%)
Gene names: mdm4, mdmx
Pfam: SWIB/MDM2 domain
InterPro:
CATH: SWIB/MDM2 domain
Protein Mdm4 in PDB entry 3dac, assembly 1, front view.
Protein Mdm4 in PDB entry 3dac, assembly 1, side view.
Protein Mdm4 in PDB entry 3dac, assembly 1, top view.
Molecule details ›

Search similar proteins

Cellular tumor antigen p53
Chains: B, P
Length: 21 amino acids
Theoretical weight: 2.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 17-37; Coverage: 5%)
Gene names: P53, TP53
Pfam: P53 transactivation motif
InterPro: p53 transactivation domain
Cellular tumor antigen p53 in PDB entry 3dac, assembly 1, front view.
Cellular tumor antigen p53 in PDB entry 3dac, assembly 1, side view.
Cellular tumor antigen p53 in PDB entry 3dac, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links