PDBe 3srv

X-ray diffraction
1.95Å resolution

Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase SYK Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 32.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43405 (Residues: 360-635; Coverage: 44%)
Gene name: SYK
Sequence domains: Protein tyrosine kinase
Structure domains:
Tyrosine-protein kinase SYK Chain: B
Molecule details ›
Chain: B
Length: 277 amino acids
Theoretical weight: 32.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43405 (Residues: 360-635; Coverage: 44%)
Gene name: SYK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P1
Unit cell:
a: 40.124Å b: 42.316Å c: 87.621Å
α: 99.68° β: 90.16° γ: 100.19°
R-values:
R R work R free
0.188 0.185 0.241
Expression system: Spodoptera frugiperda