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Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor

X-ray diffraction
1.95Å resolution
PDB entry 3srv coloured by chain, front view.
PDB entry 3srv coloured by chain, side view.
PDB entry 3srv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase SYK
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Multimeric state: monomeric
Accessible surface area: 13223.42 Å2
Buried surface area: 630.34 Å2
Dissociation area: 58.86 Å2
Dissociation energy (ΔGdiss): 0.18 kcal/mol
Dissociation entropy (TΔSdiss): 0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155056
Assembly 2
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Assembly Name: Tyrosine-protein kinase SYK
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Multimeric state: monomeric
Accessible surface area: 13170.56 Å2
Buried surface area: 178.59 Å2
Dissociation area: 89.3 Å2
Dissociation energy (ΔGdiss): 0.45 kcal/mol
Dissociation entropy (TΔSdiss): 0.89 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155056

Macromolecules

Tyrosine-protein kinase SYK
Chain: A
Length: 277 amino acids
Theoretical weight: 32.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43405 (Residues: 360-635; Coverage: 44%)
Gene name: SYK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase SYK in PDB entry 3srv, assembly 1, front view.
Tyrosine-protein kinase SYK in PDB entry 3srv, assembly 1, side view.
Tyrosine-protein kinase SYK in PDB entry 3srv, assembly 1, top view.
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Tyrosine-protein kinase SYK
Chain: B
Length: 277 amino acids
Theoretical weight: 32.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43405 (Residues: 360-635; Coverage: 44%)
Gene name: SYK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase SYK in PDB entry 3srv, assembly 2, front view.
Tyrosine-protein kinase SYK in PDB entry 3srv, assembly 2, side view.
Tyrosine-protein kinase SYK in PDB entry 3srv, assembly 2, top view.
Molecule details ›

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