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Crystal Structure of the bromodomain of human BRD1

X-ray diffraction
2.21Å resolution
PDB entry 3rcw coloured by chain, front view.
PDB entry 3rcw coloured by chain, side view.
PDB entry 3rcw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Bromodomain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 7621.05 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131987
Assembly 2
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Assembly Name: Bromodomain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 7632.21 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131987
Assembly 3 (preferred)
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Assembly Name: Bromodomain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 6789.35 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131987
Assembly 4
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Assembly Name: Bromodomain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 7127.38 Å2
Buried surface area: 186.74 Å2
Dissociation area: 93.37 Å2
Dissociation energy (ΔGdiss): 0.32 kcal/mol
Dissociation entropy (TΔSdiss): -0.36 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131987
Assembly 5
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Assembly Name: Bromodomain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 7424.91 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131987
Assembly 6
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Assembly Name: Bromodomain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 6891.14 Å2
Buried surface area: 186.34 Å2
Dissociation area: 93.17 Å2
Dissociation energy (ΔGdiss): -1.34 kcal/mol
Dissociation entropy (TΔSdiss): -0.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131987
Assembly 7
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Assembly Name: Bromodomain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 6848.36 Å2
Buried surface area: 201.61 Å2
Dissociation area: 100.8 Å2
Dissociation energy (ΔGdiss): -0.23 kcal/mol
Dissociation entropy (TΔSdiss): -0.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131987
Assembly 8
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Assembly Name: Bromodomain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 6634.75 Å2
Buried surface area: 196.67 Å2
Dissociation area: 98.33 Å2
Dissociation energy (ΔGdiss): 1.76 kcal/mol
Dissociation entropy (TΔSdiss): -0.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131987

Macromolecules

Bromodomain-containing protein 1
Chains: A, B, C, D, E, F, G, H
Length: 135 amino acids
Theoretical weight: 15.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95696 (Residues: 556-688; Coverage: 13%)
Gene names: BRD1, BRL, BRPF2
Pfam: Bromodomain
InterPro:
CATH: Bromodomain-like
Bromodomain-containing protein 1 in PDB entry 3rcw, assembly 3, front view.
Bromodomain-containing protein 1 in PDB entry 3rcw, assembly 3, side view.
Bromodomain-containing protein 1 in PDB entry 3rcw, assembly 3, top view.
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