3lju › Citations

Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.

Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, MacKenzie F, Chishti AH, Park HW
Proc Natl Acad Sci U S A 107 20346-51 (2010)
Related entries: 3feh, 3fm8

Cited: 37 times
EuropePMC logo PMID: 21057110

Abstract

Phosphatidylinositol 3,4,5-triphosphate (PIP3) plays a key role in neuronal polarization and axon formation. PIP3-containing vesicles are transported to axon tips by the kinesin KIF13B via an adaptor protein, centaurin α1 (CENTA1). KIF13B interacts with CENTA1 through its forkhead-associated (FHA) domain. We solved the crystal structures of CENTA1 in ligand-free, KIF13B-FHA domain-bound, and PIP3 head group (IP4)-bound conformations, and the CENTA1/KIF13B-FHA/IP4 ternary complex. The first pleckstrin homology (PH) domain of CENTA1 specifically binds to PIP3, while the second binds to both PIP3 and phosphatidylinositol 3,4-biphosphate (PI(3,4)P(2)). The FHA domain of KIF13B interacts with the PH1 domain of one CENTA1 molecule and the ArfGAP domain of a second CENTA1 molecule in a threonine phosphorylation-independent fashion. We propose that full-length KIF13B and CENTA1 form heterotetramers that can bind four phosphoinositide molecules in the vesicle and transport it along the microtubule.

Reviews - 3lju mentioned but not cited (1)

  1. Creativity comes from interactions: modules of protein interactions in plants. Allen JR, Wilkinson EG, Strader LC. FEBS J 289 1492-1514 (2022)

Articles - 3lju mentioned but not cited (6)

  1. The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells. Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM. J Biol Chem 290 20827-20840 (2015)
  2. The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3). Pilling C, Landgraf KE, Falke JJ. Biochemistry 50 9845-9856 (2011)
  3. Significant reduction in errors associated with nonbonded contacts in protein crystal structures: automated all-atom refinement with PrimeX. Bell JA, Ho KL, Farid R. Acta Crystallogr D Biol Crystallogr 68 935-952 (2012)
  4. Systematic simulation of the interactions of pleckstrin homology domains with membranes. Le Huray KIP, Wang H, Sobott F, Kalli AC. Sci Adv 8 eabn6992 (2022)
  5. The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. Chakraborty S, Rendón-Ramírez A, Ásgeirsson B, Dutta M, Ghosh AS, Oda M, Venkatramani R, Rao BJ, Dandekar AM, Goñi FM. F1000Res 2 286 (2013)
  6. Mutations in the ARAP3 Gene in Three Families with Primary Lymphedema Negative for Mutations in Known Lymphedema-Associated Genes. Ricci M, Compagna R, Amato B, Kenanoglu S, Veselenyiova D, Kurti D, Baglivo M, Basha SH, Serrani R, Miggiano GAD, Aquilanti B, Matera G, Marceddu G, Velluti V, Gagliardi L, Dundar M, Krajcovic J, Bertelli M, Bertelli M. Int J Genomics 2020 3781791 (2020)


Reviews citing this publication (9)

  1. Regulation of small GTPases by GEFs, GAPs, and GDIs. Cherfils J, Zeghouf M. Physiol Rev 93 269-309 (2013)
  2. Intracellular Cargo Transport by Kinesin-3 Motors. Siddiqui N, Straube A. Biochemistry (Mosc) 82 803-815 (2017)
  3. FHA domains: Phosphopeptide binding and beyond. Almawi AW, Matthews LA, Guarné A. Prog Biophys Mol Biol 127 105-110 (2017)
  4. Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins. Morthorst SK, Christensen ST, Pedersen LB. FEBS J 285 4535-4564 (2018)
  5. Cytoskeleton Molecular Motors: Structures and Their Functions in Neuron. Xiao Q, Hu X, Wei Z, Tam KY. Int J Biol Sci 12 1083-1092 (2016)
  6. Dbf4: the whole is greater than the sum of its parts. Matthews LA, Guarné A. Cell Cycle 12 1180-1188 (2013)
  7. Regulators and Effectors of Arf GTPases in Neutrophils. Gamara J, Chouinard F, Davis L, Aoudjit F, Bourgoin SG. J Immunol Res 2015 235170 (2015)
  8. Phosphoregulation of Kinesins Involved in Long-Range Intracellular Transport. Kumari D, Ray K. Front Cell Dev Biol 10 873164 (2022)
  9. The role of forkhead-associated (FHA)-domain proteins in plant biology. Wang Q. Plant Mol Biol 111 455-472 (2023)

Articles citing this publication (21)

  1. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B. Xing BM, Yang YR, Du JX, Chen HJ, Qi C, Huang ZH, Zhang Y, Wang Y. J Neurosci 32 14709-14721 (2012)
  2. A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations. Bentley M, Decker H, Luisi J, Banker G. J Cell Biol 208 273-281 (2015)
  3. Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily. Lenoir M, Kufareva I, Abagyan R, Overduin M. Membranes (Basel) 5 646-663 (2015)
  4. Crystal structure of Arabidopsis thaliana Dawdle forkhead-associated domain reveals a conserved phospho-threonine recognition cleft for dicer-like 1 binding. Machida S, Yuan YA. Mol Plant 6 1290-1300 (2013)
  5. SsaA, a member of a novel class of transcriptional regulators, controls sansanmycin production in Streptomyces sp. strain SS through a feedback mechanism. Li Q, Wang L, Xie Y, Wang S, Chen R, Hong B. J Bacteriol 195 2232-2243 (2013)
  6. A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins. Matthews LA, Selvaratnam R, Jones DR, Akimoto M, McConkey BJ, Melacini G, Duncker BP, Guarné A. J Biol Chem 289 2589-2599 (2014)
  7. Glucocerebrosidase involvement in Parkinson disease and other synucleinopathies. Almeida Mdo R. Front Neurol 3 65 (2012)
  8. Role of Host Type IA Phosphoinositide 3-Kinase Pathway Components in Invasin-Mediated Internalization of Yersinia enterocolitica. Dowd GC, Bhalla M, Kean B, Thomas R, Ireton K. Infect Immun 84 1826-1841 (2016)
  9. Structure and interactions of the cytoplasmic domain of the Yersinia type III secretion protein YscD. Gamez A, Mukerjea R, Alayyoubi M, Ghassemian M, Ghosh P. J Bacteriol 194 5949-5958 (2012)
  10. De novo missense variants disrupting protein-protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types. Chen S, Wang J, Cicek E, Roeder K, Yu H, Devlin B. Mol Autism 11 76 (2020)
  11. Refinement of protein-protein complexes in contact map space with metadynamics simulations. Pfeiffenberger E, Bates PA. Proteins 87 12-22 (2019)
  12. Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A. Ren J, Huo L, Wang W, Zhang Y, Li W, Lou J, Xu T, Feng W. J Biol Chem 291 3581-3594 (2016)
  13. KIF13A drives AMPA receptor synaptic delivery for long-term potentiation via endosomal remodeling. Gutiérrez Y, López-García S, Lario A, Gutiérrez-Eisman S, Delevoye C, Esteban JA. J Cell Biol 220 e202003183 (2021)
  14. ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis. Ramirez NP, Lee J, Zheng Y, Li L, Dennis B, Chen D, Challa A, Planelles V, Westover KD, Alto NM, D'Orso I. Nat Commun 13 1109 (2022)
  15. Structural insights into the recognition of phosphorylated Hop1 by Mek1. Xie C, He C, Jiang Y, Yu H, Cheng L, Nshogoza G, Ala MS, Tian C, Wu J, Shi Y, Li F. Acta Crystallogr D Struct Biol 74 1027-1038 (2018)
  16. In vitro reconstitution reveals phosphoinositides as cargo-release factors and activators of the ARF6 GAP ADAP1. Duellberg C, Auer A, Canigova N, Loibl K, Loose M. Proc Natl Acad Sci U S A 118 e2010054118 (2021)
  17. The Kinesin-3 motor, KLP-4, mediates axonal organization and cholinergic signaling in Caenorhabditis elegans. Magaletta ME, Perkins KJ, Deuchler CP, Pieczynski JN. FASEB Bioadv 1 450-460 (2019)
  18. A novel approach in preventing vascular leakage and angiogenesis in wet age-related macular degeneration. Yamada KH. Neural Regen Res 17 1751-1752 (2022)
  19. Afadin couples RAS GTPases to the polarity rheostat Scribble. Goudreault M, Gagné V, Jo CH, Singh S, Killoran RC, Gingras AC, Smith MJ. Nat Commun 13 4562 (2022)
  20. Control of motor landing and processivity by the CAP-Gly domain in the KIF13B tail. Fan X, McKenney RJ. Nat Commun 14 4715 (2023)
  21. Functional Role of AGAP2/PIKE-A in Fcγ Receptor-Mediated Phagocytosis. Chouinard FC, Davis L, Gilbert C, Bourgoin SG. Cells 12 72 (2022)


Quick links