PDBe 3fm8

X-ray diffraction
2.3Å resolution

Crystal structure of full length centaurin alpha-1 bound with the FHA domain of KIF13B (CAPRI target)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Arf-GAP with dual PH domain-containing protein 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 392 amino acids
Theoretical weight: 45.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75689 (Residues: 1-374; Coverage: 100%)
Gene names: ADAP1, CENTA1
Sequence domains:
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Kinesin-like protein KIF13B Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQT8 (Residues: 440-545; Coverage: 6%)
Gene names: GAKIN, KIAA0639, KIF13B
Sequence domains: FHA domain
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41212
Unit cell:
a: 115.632Å b: 115.632Å c: 189.291Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.231 0.272
Expression system: Escherichia coli