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Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313

X-ray diffraction
2.1Å resolution
PDB entry 3c4h coloured by chain, front view.
PDB entry 3c4h coloured by chain, side view.
PDB entry 3c4h coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein mono-ADP-ribosyltransferase PARP3
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Multimeric state: monomeric
Accessible surface area: 17258.04 Å2
Buried surface area: 256.72 Å2
Dissociation area: 128.36 Å2
Dissociation energy (ΔGdiss): -1.72 kcal/mol
Dissociation entropy (TΔSdiss): 0.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-195358

Macromolecules

Protein mono-ADP-ribosyltransferase PARP3
Chain: A
Length: 357 amino acids
Theoretical weight: 39.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y6F1 (Residues: 178-532; Coverage: 67%)
Gene names: ADPRT3, ADPRTL3, PARP3
Pfam:
InterPro:
CATH:
Protein mono-ADP-ribosyltransferase PARP3 in PDB entry 3c4h, assembly 1, front view.
Protein mono-ADP-ribosyltransferase PARP3 in PDB entry 3c4h, assembly 1, side view.
Protein mono-ADP-ribosyltransferase PARP3 in PDB entry 3c4h, assembly 1, top view.
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