Domain

Poly(ADP-ribose) polymerase, regulatory domain (IPR004102)

Short name: Poly(ADP-ribose)pol_reg_dom

Overlapping homologous superfamilies

Domain relationships

None.

Description

Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The regulatory domain of the polymerase is almost always associated with the C-terminal catalytic domain (see IPR012317).

This domain consists of a duplication of two helix-loop-helix structural repeats [PMID: 9521710].

GO terms

Biological Process

GO:0006471 protein ADP-ribosylation

Molecular Function

GO:0003950 NAD+ ADP-ribosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles