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Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase

X-ray diffraction
1.84Å resolution
PDB entry 2x1u coloured by chain, front view.
PDB entry 2x1u coloured by chain, side view.
PDB entry 2x1u coloured by chain, top view.
Source organism: Trypanosoma brucei brucei
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Triosephosphate isomerase, glycosomal
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Multimeric state: monomeric
Accessible surface area: 10178.59 Å2
Buried surface area: 646.36 Å2
Dissociation area: 88.31 Å2
Dissociation energy (ΔGdiss): 12.02 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138175
Assembly 2
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Assembly Name: Triosephosphate isomerase, glycosomal
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Multimeric state: monomeric
Accessible surface area: 10671.82 Å2
Buried surface area: 614.33 Å2
Dissociation area: 58.35 Å2
Dissociation energy (ΔGdiss): 7.78 kcal/mol
Dissociation entropy (TΔSdiss): 0.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138175

Macromolecules

Triosephosphate isomerase, glycosomal
Chains: A, B
Length: 238 amino acids
Theoretical weight: 25.66 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P04789 (Residues: 2-250; Coverage: 95%)
Pfam: Triosephosphate isomerase
InterPro:
CATH: Aldolase class I
Triosephosphate isomerase, glycosomal in PDB entry 2x1u, assembly 1, front view.
Triosephosphate isomerase, glycosomal in PDB entry 2x1u, assembly 1, side view.
Triosephosphate isomerase, glycosomal in PDB entry 2x1u, assembly 1, top view.
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