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HhaI DNA methyltransferase R163N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH

Source organisms:
Biochemical function: methyltransferase activity
Biological process: methylation
Cellular component: not assigned

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EC 2.1.1.37: DNA (cytosine-5-)-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
Systematic name:
S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
Alternative Name(s):
  • Cytosine 5-methyltransferase
  • Cytosine DNA methylase
  • Cytosine DNA methyltransferase
  • Cytosine-specific DNA methyltransferase
  • DNA 5-cytosine methylase
  • DNA cytosine C(5) methylase
  • DNA cytosine c(5) methylase
  • DNA cytosine methylase
  • DNA methylase
  • DNA methyltransferase
  • DNA transmethylase
  • DNA-cytosine 5-methylase
  • DNA-cytosine methyltransferase
  • Deoxyribonucleate methylase
  • Deoxyribonucleate methyltransferase
  • Deoxyribonucleic (cytosine-5-)-methyltransferase
  • Deoxyribonucleic acid (cytosine-5-)-methyltransferase
  • Deoxyribonucleic acid methylase
  • Deoxyribonucleic acid methyltransferase
  • Deoxyribonucleic acid modification methylase
  • Deoxyribonucleic methylase
  • EcoRI methylase
  • HpaII methylase
  • HpaII' methylase
  • M.BsuRIa
  • M.BsuRIb
  • Methylphosphotriester-DNA methyltransferase
  • Modification methylase
  • Restriction-modification system
  • Site-specific DNA-methyltransferase (cytosine-specific)
  • Typ II DNA methylase
  • Type II DNA methylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00145
Domain description: C-5 cytosine-specific DNA methylase
Occurring in:
  1. Type II methyltransferase M.HhaI
The deposited structure of PDB entry 2uyc contains 1 copy of Pfam domain PF00145 (C-5 cytosine-specific DNA methylase) in Type II methyltransferase M.HhaI. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001525
Domain description: C-5 cytosine methyltransferase
Occurring in:
  1. Type II methyltransferase M.HhaI
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Type II methyltransferase M.HhaI
IPR031303
Domain description: DNA methylase, C-5 cytosine-specific, conserved site
Occurring in:
  1. Type II methyltransferase M.HhaI
IPR018117
Domain description: DNA methylase, C-5 cytosine-specific, active site
Occurring in:
  1. Type II methyltransferase M.HhaI

Structure domains

CATH CATH domains
3.40.50.150
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Vaccinia Virus protein VP39
Occurring in:
  1. Type II methyltransferase M.HhaI
The deposited structure of PDB entry 2uyc contains 1 copy of CATH domain 3.40.50.150 (Rossmann fold) in Type II methyltransferase M.HhaI. Showing 1 copy in chain A.
3.90.120.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: DNA Methylase; Chain A, domain 2
Homology: DNA Methylase, subunit A, domain 2
Occurring in:
  1. Type II methyltransferase M.HhaI
The deposited structure of PDB entry 2uyc contains 1 copy of CATH domain 3.90.120.10 (DNA Methylase; Chain A, domain 2) in Type II methyltransferase M.HhaI. Showing 1 copy in chain A.

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