C-5 cytosine methyltransferase (IPR001525)

Short name: C5_MeTfrase

Overlapping homologous superfamilies

Family relationships


C-5 cytosine-specific DNA methylases (EC: (C5 Mtase) are enzymes that specifically methylate the C-5 carbon of cytosines in DNA to produce C5-methylcytosine [PMID: 3248729, PMID: 8127644, PMID: 2716049]. In mammalian cells, cytosine-specific methyltransferases methylate certain CpG sequences, which are believed to modulate gene expression and cell differentiation. In bacteria, these enzymes are a component of restriction-modification systems and serve as valuable tools for the manipulation of DNA [PMID: 7773746, PMID: 8127644]. The structure of HhaI methyltransferase (M.HhaI) has been resolved to 2.5 A [PMID: 8343957]: the molecule folds into 2 domains - a larger catalytic domain containing catalytic and cofactor binding sites, and a smaller DNA recognition domain.

This entry also includes tRNA (cytosine(38)-C(5))-methyltransferase (EC:, also known as DNMT2 (DNA (cytosine-5)-methyltransferase-like protein 2), that specifically methylates cytosine 38 in the anticodon loop of tRNA (Asp) [PMID: 16424344].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008168 methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles