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Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome

X-ray diffraction
2.4Å resolution
PDB entry 2pzp coloured by chain, front view.
PDB entry 2pzp coloured by chain, side view.
PDB entry 2pzp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fibroblast growth factor receptor 2
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Multimeric state: homo dimer
Accessible surface area: 24691.27 Å2
Buried surface area: 4786.74 Å2
Dissociation area: 1,067.18 Å2
Dissociation energy (ΔGdiss): 2.42 kcal/mol
Dissociation entropy (TΔSdiss): 13.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149430

Macromolecules

Fibroblast growth factor receptor 2
Chains: A, B
Length: 324 amino acids
Theoretical weight: 37.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 458-768; Coverage: 39%)
Gene names: BEK, FGFR2, KGFR, KSAM
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Fibroblast growth factor receptor 2 in PDB entry 2pzp, assembly 1, front view.
Fibroblast growth factor receptor 2 in PDB entry 2pzp, assembly 1, side view.
Fibroblast growth factor receptor 2 in PDB entry 2pzp, assembly 1, top view.
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