Structure analysis

Crystal structure of the ER alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol

X-ray diffraction
1.94Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 20740.11 Å2
Buried surface area: 7224.84 Å2
Dissociation area: 523 Å2
Dissociation energy (ΔGdiss): 2.93 kcal/mol
Dissociation entropy (TΔSdiss): 7.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-136928
Complex Portal ID: CPX-5156

Macromolecules

Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 298-554; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor

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Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

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