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STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS

X-ray diffraction
2.25Å resolution
PDB entry 2lpr coloured by chain, front view.
PDB entry 2lpr coloured by chain, side view.
PDB entry 2lpr coloured by chain, top view.
Source organism: Lysobacter enzymogenes
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-lytic protease and peptide
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Multimeric state: hetero dimer
Accessible surface area: 7711.63 Å2
Buried surface area: 1046.61 Å2
Dissociation area: 296.58 Å2
Dissociation energy (ΔGdiss): 2.05 kcal/mol
Dissociation entropy (TΔSdiss): 3.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133513

Macromolecules

Alpha-lytic protease
Chain: A
Length: 198 amino acids
Theoretical weight: 19.82 KDa
Source organism: Lysobacter enzymogenes
Expression system: Escherichia coli
UniProt:
  • Canonical: P00778 (Residues: 200-397; Coverage: 53%)
Gene name: alpha-LP
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Prokaryotic proteases
Alpha-lytic protease in PDB entry 2lpr, assembly 1, front view.
Alpha-lytic protease in PDB entry 2lpr, assembly 1, side view.
Alpha-lytic protease in PDB entry 2lpr, assembly 1, top view.
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METHOXYSUCCINYL-ALA-ALA-PRO-VALINE BORONIC ACID INHIBITOR
Chain: P
Length: 5 amino acids
Theoretical weight: 470 Da
Source organism: Lysobacter enzymogenes
Expression system: Not provided
METHOXYSUCCINYL-ALA-ALA-PRO-VALINE BORONIC ACID INHIBITOR in PDB entry 2lpr, assembly 1, front view.
METHOXYSUCCINYL-ALA-ALA-PRO-VALINE BORONIC ACID INHIBITOR in PDB entry 2lpr, assembly 1, side view.
METHOXYSUCCINYL-ALA-ALA-PRO-VALINE BORONIC ACID INHIBITOR in PDB entry 2lpr, assembly 1, top view.
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