› 2jfb

X-ray diffraction
2.5Å resolution

3D Structure of Lumazine Synthase from Candida albicans

Released:
DOI: 10.2210/pdb2jfb/pdb
PDB entry 2jfb coloured by chain, front view.
PDB entry 2jfb coloured by chain, side view.
PDB entry 2jfb coloured by chain, top view.
Source organism: Candida albicans
Primary publication:
Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design.
Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R
J Biol Chem 282 17231-41 (2007)
PMID: 17446177

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162774 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
Length: 164 amino acids
Theoretical weight: 18.16 KDa
Source organism: Candida albicans
Expression system: Escherichia coli
Structure domains: Lumazine/riboflavin synthase

Ligands and Environments

2 bound ligands:
Ligand PO4 15 x PO4
Ligand MPD 3 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P3121
Unit cell:
a: 128.648Å b: 128.648Å c: 284.965Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.21 0.26
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Genetic control of biosynthesis and transport of riboflavin and flavin nucleotides and construction of robust biotechnological producers.
Abbas et al. (2011)
12 more

2 mentions without citation

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens.
Ueda et al. (2020)
1 more