6,7-dimethyl-8-ribityllumazine synthase (IPR002180)
Short name: DMRL_synthase
- 6,7-dimethyl-8-ribityllumazine synthase (IPR002180)
- 6,7-dimethyl-8-ribityllumazine synthase, chloroplast (IPR017420)
- Riboflavin synthase, archaeal (IPR006399)
6,7-dimethyl-8-ribityllumazine synthase (riboflavin synthase) catalyses the biosynthesis of riboflavin according to the reaction:
The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates. The final step in the biosynthesis of the vitamin involves the dismutation of 6,7-dimethyl-8-ribityllumazine catalyzed by riboflavin synthase. The second product, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, is recycled in the biosynthetic pathway by 6,7-dimethyl-8-ribityllumazine synthase [PMID: 18298940]. N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives inhibit riboflavin synthase [PMID: 18331058].
This family includes the beta chain of 6,7-dimethyl-8-ribityllumazine synthase EC:220.127.116.11. The family also includes a subfamily of distant archaebacterial proteins that may also have the same function for example O28856.
- MF_00178 (Lumazine_synth)
- G3DSA:18.104.22.1680 (G3DSA:22.214.171.1240)
- SSF52121 (SSF52121)
- PTHR21058 (PTHR21058)
- PF00885 (DMRL_synthase)
- TIGR00114 (lumazine-synth)