Family

6,7-dimethyl-8-ribityllumazine synthase (IPR002180)

Short name: DMRL_synthase

Family relationships

Description

6,7-dimethyl-8-ribityllumazine synthase (riboflavin synthase) catalyses the biosynthesis of riboflavin according to the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates. The final step in the biosynthesis of the vitamin involves the dismutation of 6,7-dimethyl-8-ribityllumazine catalyzed by riboflavin synthase. The second product, 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, is recycled in the biosynthetic pathway by 6,7-dimethyl-8-ribityllumazine synthase [PMID: 18298940]. N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives inhibit riboflavin synthase [PMID: 18331058].

This family includes the beta chain of 6,7-dimethyl-8-ribityllumazine synthase EC:2.5.1.9. The family also includes a subfamily of distant archaebacterial proteins that may also have the same function for example O28856.

GO terms

Biological Process

GO:0009231 riboflavin biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0009349 riboflavin synthase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP
GENE3D
SUPERFAMILY
PANTHER
Pfam
TIGRFAMs