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Crystal Structure of a Nicotinate Phosphoribosyltransferase from Thermoplasma acidophilum

Source organism: Thermoplasma acidophilum
Biochemical function: metal ion binding
Biological process: pyridine nucleotide biosynthetic process
Cellular component: not assigned

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EC 6.3.4.21: Nicotinate phosphoribosyltransferase

Reaction catalysed:
Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
Systematic name:
5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming)
Alternative Name(s):
  • Niacin ribonucleotidase
  • Nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase
  • Nicotinic acid mononucleotide glycohydrolase
  • Nicotinic acid mononucleotide pyrophosphorylase
  • Nicotinic acid phosphoribosyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01729
Domain description: Quinolinate phosphoribosyl transferase, C-terminal domain
Occurring in:
  1. Putative nicotinate phosphoribosyltransferase
The deposited structure of PDB entry 2i1o contains 1 copy of Pfam domain PF01729 (Quinolinate phosphoribosyl transferase, C-terminal domain) in Putative nicotinate phosphoribosyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036068
Domain description: Nicotinate phosphoribosyltransferase-like, C-terminal
Occurring in:
  1. Putative nicotinate phosphoribosyltransferase
IPR002638
Domain description: Quinolinate phosphoribosyl transferase, C-terminal
Occurring in:
  1. Putative nicotinate phosphoribosyltransferase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Putative nicotinate phosphoribosyltransferase
IPR007229
Domain description: Nicotinate phosphoribosyltransferase family
Occurring in:
  1. Putative nicotinate phosphoribosyltransferase
IPR035809
Domain description: Nicotinate phosphoribosyltransferase, archaeal-type
Occurring in:
  1. Putative nicotinate phosphoribosyltransferase
IPR037128
Domain description: Quinolinate phosphoribosyl transferase, N-terminal domain superfamily
Occurring in:
  1. Putative nicotinate phosphoribosyltransferase

Structure domains

CATH CATH domains
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Putative nicotinate phosphoribosyltransferase
The deposited structure of PDB entry 2i1o contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in Putative nicotinate phosphoribosyltransferase. Showing 1 copy in chain A.
3.90.1170.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aldehyde Oxidoreductase; domain 3
Homology: Quinolinate phosphoribosyl transferase, N-terminal domain
Occurring in:
  1. Putative nicotinate phosphoribosyltransferase
The deposited structure of PDB entry 2i1o contains 1 copy of CATH domain 3.90.1170.20 (Aldehyde Oxidoreductase; domain 3) in Putative nicotinate phosphoribosyltransferase. Showing 1 copy in chain A.

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