Nicotinate phosphoribosyltransferase family (IPR007229)

Short name: Nic_PRibTrfase-Fam

Overlapping homologous superfamilies

Family relationships


Nicotinate phosphoribosyltransferase (EC: is the rate-limiting enzyme that catalyses the first reaction in the NAD salvage synthesis [PMID: 18490451]. Members in this family can be split into two further subfamilies represented in IPR006405 and IPR006406. Members in IPR006405 have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. However, one argument suggesting that this family represents the same enzyme is that no species has a member of both subfamilies. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.