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Crystal structure of the phosphotyrosyl phosphatase activator

Source organism: Homo sapiens
Biochemical function: protein phosphatase 2A binding
Biological process: positive regulation of apoptotic process
Cellular component: ATPase complex

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EC 5.2.1.8: Peptidylprolyl isomerase

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
  • Cyclophilin
  • PPIase
  • Peptide bond isomerase
  • Peptidyl-prolyl cis-trans isomerase
  • Peptidylprolyl cis-trans isomerase
  • Rotamase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03095
Domain description: Phosphotyrosyl phosphate activator (PTPA) protein
Occurring in:
  1. Serine/threonine-protein phosphatase 2A activator
The deposited structure of PDB entry 2hv6 contains 2 copies of Pfam domain PF03095 (Phosphotyrosyl phosphate activator (PTPA) protein) in Serine/threonine-protein phosphatase 2A activator. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004327
Domain description: Phosphotyrosyl phosphatase activator, PTPA
Occurring in:
  1. Serine/threonine-protein phosphatase 2A activator
IPR043170
Domain description: Phosphotyrosyl phosphatase activator, C-terminal lid domain
Occurring in:
  1. Serine/threonine-protein phosphatase 2A activator
IPR037218
Domain description: PTPA superfamily
Occurring in:
  1. Serine/threonine-protein phosphatase 2A activator

Structure domain

CATH CATH domain
1.20.120.1150
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Occurring in:
  1. Serine/threonine-protein phosphatase 2A activator
The deposited structure of PDB entry 2hv6 contains 2 copies of CATH domain 1.20.120.1150 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in Serine/threonine-protein phosphatase 2A activator. Showing 1 copy in chain A.
SCOP SCOP annotation
140985
Class: All alpha proteins
Fold: PTPA-like
Superfamily: PTPA-like
Occurring in:
  1. Serine/threonine-protein phosphatase 2A activator
The deposited structure of PDB entry 2hv6 contains 2 copies of SCOP domain 140985 (PTPA-like) in Serine/threonine-protein phosphatase 2A activator. Showing 1 copy in chain A.

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