PDBe 2hv6

X-ray diffraction
1.9Å resolution

Crystal structure of the phosphotyrosyl phosphatase activator

Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0). 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/threonine-protein phosphatase 2A activator Chains: A, B
Molecule details ›
Chains: A, B
Length: 323 amino acids
Theoretical weight: 36.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q15257 (Residues: 1-358; Coverage: 90%)
  • Best match: Q15257-2 (Residues: 1-323)
Gene names: PPP2R4, PTPA

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 158.25Å b: 42.79Å c: 75.57Å
α: 90° β: 108.83° γ: 90°
R R work R free
0.19 0.183 0.239
Expression system: Escherichia coli BL21(DE3)