PDBe 2d1x

X-ray diffraction
1.9Å resolution

The crystal structure of the cortactin-SH3 domain and AMAP1-peptide complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Src substrate cortactin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 66 amino acids
Theoretical weight: 7.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q14247 (Residues: 490-550; Coverage: 11%)
Gene names: CTTN, EMS1
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 15 amino acids
Theoretical weight: 1.69 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9ULH1 (Residues: 823-837; Coverage: 1%)
Gene names: ASAP1, DDEF1, KIAA1249

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C2221
Unit cell:
a: 71.45Å b: 132.14Å c: 61.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.226
Expression systems:
  • Escherichia coli BL21
  • Not provided