Cortactin, SH3 domain (IPR035716)

Short name: Cortactin_SH3

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • Cortactin, SH3 domain (IPR035716)


Cortactin was originally identified as a substrate of Src kinase [PMID: 2110361]. It is an actin regulatory protein that binds to the Arp2/3 complex and stabilizes branched actin filaments [PMID: 19437513, PMID: 18615630]. It is involved in cellular processes that affect cell motility, adhesion, migration, endocytosis, and invasion [PMID: 11607842, PMID: 21258212, PMID: 16474900, PMID: 16990456].

Cortactin contains an N-terminal acidic domain, several copies of a repeat domain found in cortactin and HS1, a proline-rich region, and a C-terminal SH3 domain [PMID: 15670811]. The N-terminal region interacts with the Arp2/3 complex and F-actin, and is crucial in regulating branched actin assembly [PMID: 16434035]. Cortactin also serves as a scaffold and provides a bridge to the actin cytoskeleton for membrane trafficking and signaling proteins that bind to its SH3 domain. Binding partners for the SH3 domain of cortactin include dynamin2, N-WASp, MIM, FGD1, among others [PMID: 21258212].

This entry represents the SH3 domain of cortactin.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.