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Human deltaF508 NBD1 with two solublizing mutations.

Source organism: Homo sapiens
Biochemical function: ATP hydrolysis activity
Biological process: not assigned
Cellular component: not assigned

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EC 5.6.1.6: Channel-conductance-controlling ATPase

Reaction catalysed:
ATP + H(2)O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel
Systematic name:
ATP phosphohydrolase (channel-conductance-controlling)
Alternative Name(s):
  • CFTR
  • Cystic-fibrosis membrane-conductance-regulating protein

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
The deposited structure of PDB entry 2bbt contains 2 copies of Pfam domain PF00005 (ABC transporter) in Cystic fibrosis transmembrane conductance regulator. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR025837
Domain description: CFTR regulator domain
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR047082
Domain description: Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette domain 1
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
The deposited structure of PDB entry 2bbt contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Cystic fibrosis transmembrane conductance regulator. Showing 1 copy in chain B.

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