Domain

CFTR regulator domain (IPR025837)

Short name: CFTR_reg_dom

Domain relationships

None.

Description

Cystic fibrosis transmembrane conductance regulator (CFTR) that belongs to the ATP-binding cassette (ABC) transporter superfamily. It is a member of the ABC-C subfamily, which also contains the SUR receptors and the multidrug- resistance associated proteins (MRP) [PMID: 11435397]. The CFTR protein encodes a chloride ion channel, which is controlled by phosphorylation. It has a major role in electrolyte and fluid secretion. CFTR is important in the determination of fluid flow, ion concentration and transepithelial salt transport. Dysfunction of the CFTR channel causes the life-threatening disease, cystic fibrosis, in which trans-epithelial ion transport is disrupted [PMID: 9922375].

This entry represents the CFTR regulator domain [PMID: 16001079, PMID: 17660831, PMID: 21059651].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam