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E. coli TS complexed with dUMP and inhibitor GA9

Source organism: Escherichia coli
Biochemical function: protein homodimerization activity
Biological process: methylation
Cellular component: cytosol

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EC 2.1.1.45: Thymidylate synthase

Reaction catalysed:
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Systematic name:
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
Alternative Name(s):
  • Methylenetetrahydrofolate:dUMP C-methyltransferase
  • TMP synthetase
  • Thymidylate synthetase
  • dTMP synthase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00303
Domain description: Thymidylate synthase
Occurring in:
  1. Thymidylate synthase
The deposited structure of PDB entry 2a9w contains 4 copies of Pfam domain PF00303 (Thymidylate synthase) in Thymidylate synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000398
Domain description: Thymidylate synthase
Occurring in:
  1. Thymidylate synthase
IPR023451
Domain description: Thymidylate synthase/dCMP hydroxymethylase domain
Occurring in:
  1. Thymidylate synthase
IPR020940
Domain description: Thymidylate synthase, active site
Occurring in:
  1. Thymidylate synthase
IPR045097
Domain description: Thymidylate synthase/dCMP hydroxymethylase
Occurring in:
  1. Thymidylate synthase
IPR036926
Domain description: Thymidylate synthase/dCMP hydroxymethylase superfamily
Occurring in:
  1. Thymidylate synthase

Structure domain

CATH CATH domain
3.30.572.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Thymidylate Synthase; Chain A
Homology: Thymidylate synthase/dCMP hydroxymethylase domain
Occurring in:
  1. Thymidylate synthase
The deposited structure of PDB entry 2a9w contains 4 copies of CATH domain 3.30.572.10 (Thymidylate Synthase; Chain A) in Thymidylate synthase. Showing 1 copy in chain A.
SCOP SCOP annotation
55832
Class: Alpha and beta proteins (a+b)
Fold: Thymidylate synthase/dCMP hydroxymethylase
Superfamily: Thymidylate synthase/dCMP hydroxymethylase
Occurring in:
  1. Thymidylate synthase
The deposited structure of PDB entry 2a9w contains 4 copies of SCOP domain 55832 (Thymidylate synthase/dCMP hydroxymethylase) in Thymidylate synthase. Showing 1 copy in chain A.

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