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Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor

X-ray diffraction
1.95Å resolution
PDB entry 2a0c coloured by chain, front view.
PDB entry 2a0c coloured by chain, side view.
PDB entry 2a0c coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin-dependent kinase 2
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Multimeric state: monomeric
Accessible surface area: 14139.23 Å2
Buried surface area: 832.7 Å2
Dissociation area: 416.35 Å2
Dissociation energy (ΔGdiss): 0.69 kcal/mol
Dissociation entropy (TΔSdiss): 4.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150313

Macromolecules

Cyclin-dependent kinase 2
Chain: X
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Cyclin-dependent kinase 2 in PDB entry 2a0c, assembly 1, front view.
Cyclin-dependent kinase 2 in PDB entry 2a0c, assembly 1, side view.
Cyclin-dependent kinase 2 in PDB entry 2a0c, assembly 1, top view.
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