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Crystal structure of human SDR family member 1

X-ray diffraction
1.8Å resolution
PDB entry 2qq5 coloured by chain, front view.
PDB entry 2qq5 coloured by chain, side view.
PDB entry 2qq5 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dehydrogenase/reductase SDR family member 1
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Multimeric state: homo dimer
Accessible surface area: 18348.8 Å2
Buried surface area: 3505.84 Å2
Dissociation area: 1,752.92 Å2
Dissociation energy (ΔGdiss): 23.29 kcal/mol
Dissociation entropy (TΔSdiss): 13.01 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-188619
Assembly 2
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Assembly Name: Dehydrogenase/reductase SDR family member 1
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Multimeric state: homo dimer
Accessible surface area: 20117.74 Å2
Buried surface area: 1736.89 Å2
Dissociation area: 868.45 Å2
Dissociation energy (ΔGdiss): 2.65 kcal/mol
Dissociation entropy (TΔSdiss): 12.76 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-188619
Assembly 3
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Assembly Name: Dehydrogenase/reductase SDR family member 1
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Multimeric state: homo tetramer
Accessible surface area: 33169.05 Å2
Buried surface area: 10540.22 Å2
Dissociation area: 1,764.27 Å2
Dissociation energy (ΔGdiss): 16.12 kcal/mol
Dissociation entropy (TΔSdiss): 14.31 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-188620

Macromolecules

Dehydrogenase/reductase SDR family member 1
Chain: A
Length: 260 amino acids
Theoretical weight: 28.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96LJ7 (Residues: 3-262; Coverage: 83%)
Gene names: DHRS1, SDR19C1
Pfam: short chain dehydrogenase
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain
Dehydrogenase/reductase SDR family member 1 in PDB entry 2qq5, assembly 1, front view.
Dehydrogenase/reductase SDR family member 1 in PDB entry 2qq5, assembly 1, side view.
Dehydrogenase/reductase SDR family member 1 in PDB entry 2qq5, assembly 1, top view.
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