Function and Biology Details
Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- P-loop containing nucleoside triphosphate hydrolase
- E2 regulatory, transactivation domain, subdomain 2
- E2 regulatory, transactivation domain
- Papillomavirus E2, N-terminal
- E2 regulatory, transactivation domain, subdomain 1
- Helicase, superfamily 3, DNA virus
- DNA helicase E1, C-terminal, Papillomavirus
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Regulatory protein E2 and Replication protein E1 (preferred)
PDBe Complex ID:
PDB-CPX-139232 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Replication protein E1
Molecule details ›
Chains: A, D, F, H, K, M
Length: 212 amino acids
Theoretical weight: 24.62 KDa
Source organism: human papillomavirus 18
Expression system: Escherichia coli
UniProt:
Sequence domains: Papillomavirus helicase
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Length: 212 amino acids
Theoretical weight: 24.62 KDa
Source organism: human papillomavirus 18
Expression system: Escherichia coli
UniProt:
- Canonical:
P06789 (Residues: 428-631; Coverage: 31%)
Sequence domains: Papillomavirus helicase
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Regulatory protein E2
Molecule details ›
Chains: B, E, G, J, L, Q
Length: 218 amino acids
Theoretical weight: 25.09 KDa
Source organism: human papillomavirus 18
Expression system: Escherichia coli
UniProt:
Sequence domains: E2 (early) protein, N terminal
Structure domains:
Length: 218 amino acids
Theoretical weight: 25.09 KDa
Source organism: human papillomavirus 18
Expression system: Escherichia coli
UniProt:
- Canonical: P06790 (Residues: 1-215; Coverage: 59%)
Sequence domains: E2 (early) protein, N terminal
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 8.2.2
Spacegroup:
P212121
Expression system: Escherichia coli
