Papillomavirus E2, N-terminal (IPR001866)

Short name: Papillomavirus_E2_N

Overlapping homologous superfamilies

Domain relationships



E2 is an early regulatory protein found in the dsDNA papillomaviruses. E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription, depending on E2RE's posiiton with regard to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 dimer complex binds to the origin of DNA replication [PMID: 1328886].

GO terms

Biological Process

GO:0006275 regulation of DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0016032 viral process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.