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Allosteric Inhibition of Protein Tyrosine Phosphatase 1B

X-ray diffraction
2.2Å resolution
PDB entry 1t48 coloured by chain, front view.
PDB entry 1t48 coloured by chain, side view.
PDB entry 1t48 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 1
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Multimeric state: monomeric
Accessible surface area: 14385.5 Å2
Buried surface area: 831.79 Å2
Dissociation area: 415.89 Å2
Dissociation energy (ΔGdiss): -3.47 kcal/mol
Dissociation entropy (TΔSdiss): 5.48 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148259

Macromolecules

Tyrosine-protein phosphatase non-receptor type 1
Chain: A
Length: 298 amino acids
Theoretical weight: 34.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18031 (Residues: 1-298; Coverage: 69%)
Gene names: PTP1B, PTPN1
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
SCOP: Higher-molecular-weight phosphotyrosine protein phosphatases
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1t48, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1t48, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1t48, assembly 1, top view.
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