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Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2A

Source organism: Homo sapiens
Biochemical function: nuclear receptor activity
Biological process: regulation of DNA-templated transcription
Cellular component: nucleus

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Nuclear receptor ROR-alpha
The deposited structure of PDB entry 1s0x contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Nuclear receptor ROR-alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003079
Domain description: Nuclear receptor ROR
Occurring in:
  1. Nuclear receptor ROR-alpha
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Nuclear receptor ROR-alpha
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Nuclear receptor ROR-alpha
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Nuclear receptor ROR-alpha

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Nuclear receptor ROR-alpha
The deposited structure of PDB entry 1s0x contains 1 copy of CATH domain 1.10.565.10 (Retinoid X Receptor) in Nuclear receptor ROR-alpha. Showing 1 copy in chain A.
SCOP SCOP annotation
48509
Class: All alpha proteins
Fold: Nuclear receptor ligand-binding domain
Superfamily: Nuclear receptor ligand-binding domain
Occurring in:
  1. Nuclear receptor ROR-alpha
The deposited structure of PDB entry 1s0x contains 1 copy of SCOP domain 48509 (Nuclear receptor ligand-binding domain) in Nuclear receptor ROR-alpha. Showing 1 copy in chain A.

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