› 1s0x

X-ray diffraction
2.2Å resolution

Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2A

Released:
DOI: 10.2210/pdb1s0x/pdb
PDB entry 1s0x coloured by chain, front view.
PDB entry 1s0x coloured by chain, side view.
PDB entry 1s0x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A.
Kallen J, Schlaeppi JM, Bitsch F, Delhon I, Fournier B
J Biol Chem 279 14033-8 (2004)
PMID: 14722075

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152899 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor ROR-alpha Chain: A
Molecule details ›
Chain: A
Length: 270 amino acids
Theoretical weight: 31.51 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35398 (Residues: 271-523; Coverage: 48%)
Gene names: NR1F1, RORA, RZRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand C3S 1 x C3S
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 54.4Å b: 49.9Å c: 60.7Å
α: 90° β: 97.8° γ: 90°
R-values:
R R work R free
0.197 0.197 0.209
Expression system: Spodoptera frugiperda

Quick links

Citations

46 review citations

Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.
Jetten AM. (2009)
45 more

11 mentions without citation

ROR nuclear receptors: structures, related diseases, and drug discovery.
Zhang et al. (2015)
10 more